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Game Boy Advance "S" Games
- Sabre Wulf
- Salt Lake 2002
- Santa Clause 3: The Escape Clause
- Scooby Doo 2: Monsters Unleashed
- Scooby Doo: Mystery Mayhem
- Scooby Doo: Unmasked
- The Scorpion King: Sword of Osiris
- Scrabble
- Scrabble Blast
- Scurge: Hive
- SD Gundam Force
- Sea Trader: Rise of Taipan
- SeaWorld: Shamu's Deep Sea Adventures
- Secret Agent Barbie
- Sega Arcade Gallery
- Sega Smash Pack
- Serious Sam
- Shaman King: Legacy of Spirits Soaring Hawk
- Shaman King: Legacy of Spirits Sprinting Wolf
- Shaman King: Master of Spirits
- Shaman King: Master of Spirits 2
- Shark Tale
- Shaun Palmer's Pro Snowboarder
- Shining Force: Resurrection of the Dark Dragon
- Shining Soul
- Shining Soul 2
- Shrek 2
- Shrek 2: Beg for Mercy
- Shrek Smash 'n' Crash Racing
- Shrek Superslam
- Shrek the Third
- Shrek: Hassle at the Castle
- Shrek: Reekin' Havoc
- Shrek: Swamp Kart Speedway
- Sigma Star Saga
- Silent Scope
- Sim City 2000
- The Simpsons: Hit and Run
- The Simpsons: Road Rage
- The Sims 2
- The Sims 2: Pets
- The Sims Bustin Out
- Sitting Ducks
- Sky Dancers
- Smashing Drive
- Sonic Advance
- Sonic Advance + Sonic Pinball Party
- Sonic Advance 2
- Sonic Advance 3
- Sonic Battle
- Sonic Pinball Party
- Sonic The Hedgehog Advance
- Sonic the Hedgehog Genesis
- Sonic X Vol. 1
- Sonic X Vol. 2
- Sorry! / Aggravation / Scrabble Junior
- A Sound of Thunder
- Spider-Man: Battle for New York
- Spider-Man: Mysterio's Menace
- Spider-Man: The Movie
- Spiderman 2
- Spiderman 3
- Spirit: Stallion of the Cimarron
- Spirits & Spells
- Splinter Cell
- SpongeBob SquarePants Vol. 1
- SpongeBob SquarePants Vol. 2
- SpongeBob SquarePants Vol. 3
- SpongeBob SquarePants: Creature from the Krusty Krab
- SpongeBob SquarePants: Lights, Camera, Pants!
- SpongeBob SquarePants: Revenge of the Flying Dutchman
- SpongeBob Squarepants: SuperSponge
- SpongeBob SquarePants: The Movie
- SpongeBob's Atlantis SquarePantis
- SpongeBob: The Battle for Bikini Bottom
- Spy Hunter
- Spy Hunter - Supersprint
- Spy Muppets: License to Croak
- Spyro 2: Season of Flame
- Spyro 3: Attack of the Rhynocs
- Spyro Orange: The Cortex Conspiracy
- Spyro: Season Of Ice
- SSX 3: Out of Bounds
- Stadium Games
- Star Wars Episode II Attack of the Clones
- Star Wars Episode II: The New Droid Army
- Star Wars Episode III: Revenge of the Sith
- Star Wars Trilogy: Apprentice of the Force
- Star Wars: Flight of the Falcon
- Star Wars: Jedi Power Battles
- Star X
- Starsky & Hutch
- Static Shock
- Strawberry Shortcake Vol. 1
- Strawberry Shortcake: Summertime Adventure
- Strawberry Shortcake: Sweet Dreams
- Street Fighter Alpha 3
- Street Jam Basketball
- Street Racing Syndicate
- Strike Force Hydra
- Stuntman
- Sudoku Fever
- Suite Life of Zack & Cody: Tipton Caper
- The Sum of All Fears
- Summon Night: Swordcraft Story
- Summon Night: Swordcraft Story 2
- Super Army War
- Super Breakout - Lunar Lander - Millipede
- Super Bubble Pop
- Super Bust-A-Move
- Super Collapse II
- Super Dodge Ball Advance
- Super Drop Zone: Intergalactic Rescue Mission
- Super Duper Sumos
- Super Ghouls N Ghosts
- Super Mario Advance
- Super Mario Advance 2: Super Mario World
- Super Mario Advance 4: Super Mario Bros. 3
- Super Mario Bros: Classic NES Series
- Super Monkey Ball Jr.
- Super Puzzle Fighter II
- Super Robot Monkey Team Vol. 1
- Super Robot Taisen Original Generation
- Super Robot Taisen: Original Generation 2
- Super Street Fighter 2X Revival
- Superman Returns: Fortress of Solitude
- Superman: Countdown to Apokolips!
- Surf's Up
- Sword of Mana
- System Info